Endocrine Abstracts

For the last ten years, genomic approaches have led to important discoveries in adrenocortical tumors, unraveling mechanisms of tumorigenesis and autonomous hormone secretion. Autonomous aldosterone secretion in primary aldosteronism is now seen as induced by abnormal intra-cellular calcium signaling in glomerulosa cells, related to somatic mutations. The most common affects KCNJ5, coding for a membrane channel. A clinical trial with macrolides -impacting this channel- is ongo...